> They are extremely vulnerable to the same drones humans are.
I am not confident about this. Human gets disabled by few small shrapnel projectiles into soft tissue. It is possible to build way more protected robot, for which you need some direct hit to disable it. That robot could also be very agile: e.g. do some evading jump at the last moment before being hit.
You're partially right compared to placebo only about 5% of people are painfree over the effect of a placebo when taking paracetamol.
Paracetamol got it's start as replacing the more effective but much more dangerous and withdrawn drug Phenacetin.
Why don't people notice that it's such a small benefit over nothing? Well because placebo effect is quite good for pain and pain is usually transitory anywhere..if you have a tension headache you're probably going to aim to relax. Turn away from the screen or even have some caffeine and those are more effective than paracetamol!
Where did you pull this 5% from? There are gazillions of studies showing higher or lower efficacies for different kinds of pain. Along with the inaccuracies about Phenacetin (whose MOA is metabolising into paracetamol).
You will indeed find various figures for various pain types all are far worse than ibuprofen.
Here is an example from the Cochrane library
> For the IHS preferred outcome of being pain free at two hours the NNT for paracetamol 1000 mg compared with placebo was 22 (95% confidence interval (CI) 15 to 40) in eight studies (5890 participants; high quality evidence), with no significant difference from placebo at one hour.
A NNT of 22 means that in absolute terms 1/22 people met the positive endpoint criteria more than placebo. This figure is usually quoted as 20% for placebo and 25% for paracetamol giving NNT of 20.
"pain free" is a long way from the pain is manageable. Pain is an understudied subject, where we have too little knowledge. Just using the word manageable is an indication of this.
That's very true, but the metric is applied to all medications you compare against that's what's important. You also just get a baseline idea of what's good by guessing what you'd accept.
Episodic tension type headache tested with ibuprofen Vs placebo NNT is 14. (Btw that's not great itself) But it's better than paracetamols often quoted figure 20.
Here's why I say it's not great. Why don't you guess some reasonable NNTs for say moderate depression treated with SSRIs, or no relapse in schizophrenia treated with an antipsychotic.
Now guess the NNT for a statin to prevent a first heart attack.
SSRI for moderate depression about 10, antipsychotics to prevent schizophrenia relapse over 2 years NNT= 3 (excellent )Statin to prevent a first heart attack 200! (This one always shocks me). Statins have a clear role of course.
Ibuprofen is better are reducing fever and managing headaches.
Paracetamol is the safer version Phenacetin. You used to be able to buy aspirin, phenacetin and caffeine..but phenacetin with withdrawn. APC when it was marketed was very popular but soon you were told to never give children aspirin for a fever so we used Paracetamol. Then Phenacetin was withdrawn and paracetamol became part of APC (like Alka selzta XS , or just the popular caffeine paracetamol combos)
Paracetamol came in as safer but similar, yet no where near effective. It captured bith the market feeling of its pros and cons. So we interpreted it as safer than alternatives (especially aspirin for children due to Reye syndrome). But also dangerous which might be why OPs view was that ibuprofen is safer.
The NNT (number of people you'd need to take it) to be headache free after 2 hours is about 12-20 for paracetamol. But only 7-10 for ibuprofen.
It's quite surprising that paracetamol became the defacto analgesic given it performs so poorly but it was historical inertia. And plenty of people argue that if we were to start over we would not make paracetamol OTC.
Here is a summary of COCHRANE evidence on Paracetamol "widely used and ineffective"[0].
It's a paradox no?
Paracetamol is only the presumed only active metabolite, and that is why paracetamol rapidly replaced phenacetin.
There is a quirk though, phenacetin actually delivers paracetamol to your brain and spine (where it primarily reduces pain) faster than an oral dose of paracetamol.
Similarly IV paracetamol is far more effective that oral paracetamol.
Phenacetin was also considered mildly addictive, and induced a gentle euphoria and then sedation.(We still see sedation after paracetamol in children and the elderly).
But general use we don't see these effects in paracetamol, why did phenacetin do this more effectively? Probably the higher peak levels around nerve endings.
These effects are both wanting of an explanation of phenacetin is just paracetamol and directly analegisic.
I guess it tracks with personal experience. I find Paracetamol is OK for fevers/generic cold symptoms but absolutely useless for a headache, Ibuprofen is the only thing that shifts them.
Well it's the only thing that shifts them now I'm in a country where I can't buy soluble aspirin and codeine OTC.
Agree about psychological impact outpacing likely actual impact, but that’s a relatively temporary phenomena as we are all adapting to the new way things work.
Productivity wise employment is far more than code production productivity in a vacuum, and productivity gains are rarely captured by employees (see famous chart on worker productivity where that correlation changed around 1970). I wouldn’t expect to see much in the next 1-2 years besides noticing effective teams increasing velocity of features.
I think people in forums like complaining about things and aren’t representative of the broader set of people who are just using the tools, so no real paradox. For vast majority of tech jobs, $200/mo is still an absolute steal in terms of what these tools offer. Only the dullest of companies would not realize this.
Fwiw in the 80s-90s computers also didn’t really register in productivity metrics. Qualitative changes occur long before accurate measurement catches up.
Because most people work for someone else and don't decide their own salaries. It's not doubling productivity, but even a 10-20% boost to productivity for a team of engineers means that, as a business, even $1k per month per seat is perfectly acceptable. For consumers and hobbyists that basically kills access.
I spent ages trying to work out if it would be possible to find a copy of the 2021 Encarta or Britannica.
Pre LLM And post COVID and perhaps the best we can hope for before AI taints all the info.
One of my prized possessions as a child was a CDROM based encyclopedia (well before the internet was common). I don't know why I liked it so much but on a rainy afternoon I'd kick up some of my favourite articles and read and learn more of them.
I know exactly what you mean — I had the same experience with CD-ROM encyclopedias. There’s something about just browsing and falling into articles that’s hard to replicate.
Part of the motivation here was to bring that kind of exploration back, but with the original 1911 text and structure.
Do they just mean it's got enough energy to complete some orbits but will decay. In the sense that if my car breaks down on the way to the grand canyon it took me to the wrong destination?
Or did it enter a often used orbit that is not usable for this satillite?
It's because they are heurists intended to be applied by knowledgeable and experienced humans.
It can be quite hard to explain when a student asks why you did something a particular way. The truthful answer is that it felt like the right way to go about it.
With some thought you can explain it partly - really justify the decision subconsciously made.
If they're asking about a conscious decision that's rarely much more helpful that you having to say that's what the regulations, or guidelines say.
Where they really learn is seeing those edge cases and gray areas
FAANG already did this all the time isn't it? Regardless of their policy. US is no better than China from my point of view. In this case, I see no difference between sending my prompts to US or China companies. At least China models are open source.
I accept that all the providers will do what I would consider unethical with my data and simply don't expose what I don't consider a price of doing the business I want.
The other criticism I see is "ask it what happened in 1989" but as a my use case isn't writing a high school history essay I simply don't care. Or believe one should seek those kind of answers from any AI. (If you're curious it simply cuts off the reply).
I fully appreciate that YMMV and what sits right for others will not align with what's acceptable to me. Anthropic and OpenAI both are in my badbooks as much as Z.ai. pick your poison as they say.
The view of Claude on HN is extremely positive and nearly every thread will have highly positive comment "that is not an ad".
I think people are seeing others just irked by the constant stream what feels like ads and reading it as Claude being somehow disliked.
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