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> 1. Biological brains are non-differentiable spiking networks much more complicated than backpropagated ANNs.

Actually it's not so obvious that the brain is not differentiable. If you do a cursory search, you'll find quite a lot of research into biologically plausible mechanism for backpropagation. Not saying the brain does backprop, we just don't know and it's not outside of the realm of plausibility



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