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You can easily take thyroid hormones and raise the metabolic rate. That is not tricky at all. Bodybuilders do it all the time to lean out. Some say a substantial fraction of the population is mildly hypothroid and meds are appropriate, cf. Broda Barnes.

Ari Whitten's "Forever Fat Loss" I think covers all the causes of obesity and debunks the major myths. There is no simple solution because the totality of modern industrialized life conspires to produce obesity. Emotional stress, lack of sleep, lack of daylight exposure, micro-nutrient deficiencies, pollution exposure, and so forth all tank metabolism. The body is made for near continuous low level outdoor activity and "working out" is not a proper substitute. You're designed to burn through large amounts of calories daily doing stuff like walking 8 miles at a leisurely pace and moving things around. Whereas the stress of a daily running habit is apt to adaptively lower the resting metabolic rate to the point it's barely useful.

Everybody unduly obsesses over the food aspects, but to the extent there is a particular food villain it's probably seed oils. Soy oil and canola oil suppress metabolism (directly interfere with mitochondria) and are quite new inventions, and are now consumed in huge quantities. Aside from that there is simple calorie over consumption driven by food reward. People are naturally attuned to much more monotonous and lower flavor diets than are readily available now.



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